A patient 3.5 hours from onset of left hemiplegia has clear hypodensity over more than one-third of the right MCA territory on CT. IV thrombolysis is withheld mainly because
Answer and why, all 4 options
Hemorrhage is bright (hyperdense) on CT; a dark area is infarcted tissue, so the scan shows completed ischemia, not bleeding.
This confuses the treatment window with the 3-hour limit of the Joint Commission STK-4 measure (arrival within 2 hours of last known well, lytic started within 3 hours); at 3.5 hours the patient is still inside the 4.5-hour window.
A proximal clot recanalizes less often with a lytic alone, which is why thrombectomy is added, but it does not bar the drug from an otherwise eligible patient.
Clear hypodensity over more than one-third of the MCA territory means that tissue is already dead; reperfusing it adds little benefit and raises the risk of symptomatic hemorrhage into the infarct, so the lytic is withheld.
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